BIOEQUIVALENCE STUDY OF 2 FORMULATIONS OF DOXYCYCLINE

A randomized, two-way, crossover bioequivalence study in 22 healthy ma le volunteers was conducted to compare 100-mg tablets of a monohydrate formulation with a hydrochloride formulation of doxycycline, The drug was given in a single dose of 100 mg, and blood samples were collecte d during the 72-hour period after drug administration. Doxycycline lev els in plasma were determined by high-performance liquid chromatograph y assay. The pharmacokinetic variables of area under the plasma concen tration-time curve, maximum concentration, time to maximum concentrati on, elimination half-life, and mean residence time were computed. The results of this study suggest that the two formulations are bioequival ent.