Pa. Thompson et al., GENETIC POLYMORPHISMS IN CATECHOL-O-METHYLTRANSFERASE, MENOPAUSAL STATUS, AND BREAST-CANCER RISK, Cancer research, 58(10), 1998, pp. 2107-2110
Polymorphic catechol-O-methyltransferase (COMT) catalyzes the O-methyl
ation of estrogen catechols, In a case-control study, we evaluated the
association of the low-activity allele (COMTMet) viith breast cancer
risk. Compared to women with COMTVal/Val, COMTMet/Met was associated w
ith an increased risk among premenopausal women [odds ratio (OR), 2.1;
confidence interval (CI), 1.4-4.3] but was inversely associated with
postmenopausal risk (OR, 0.4; CI, 0.2-0.7). The association of risk wi
th at least one low-activity COMTMet allele was strongest among the he
aviest premenopausal a omen (OR, 5.7; CI, 1.1-30.1) and among the lean
est postmenopausal women (OR, 0.3; CI, 0.1-0.7), suggesting that COMT,
mediated by body mass index, may be playing differential roles in hum
an breast carcinogenesis, dependent upon menopausal status.