A. Radunovic et al., UPTAKE OF ALUMINUM AND GALLIUM INTO TISSUES OF THE RAT - INFLUENCE OFANTIBODY AGAINST THE TRANSFERRIN RECEPTOR, Biological trace element research, 62(1-2), 1998, pp. 51-64
Transport of aluminum and gallium from blood into rat tissues followin
g continuous iv infusion of metals in different chemical forms has bee
n investigated. Tissue uptake of aluminum and gallium was similar and
highly dependent on the chemical species of the metals. Aluminum and g
allium accumulated in liver and spleen when infused in the chloride fo
rm. Raised citrate markedly enhanced aluminum and gallium uptake into
renal cortex and bone; in contrast with gallium-transferrin, citrate i
ncreased uptake of Ga-67 into renal cortex and bone by 8- and 14-fold
respectively. Uptake of Ga-67 with citrate into renal cortex was aroun
d 3 times smaller than that of aluminum. The antitransferrin receptor
antibody OX-26 enhanced Ga-67 uptake from gallium citrate into all rat
tissues. Ga-67 from purified gallium-transferrin was also taken into
all, tissues in the presence of OX-26, the effect being greatest in re
nal cortex and bone. No influence of antibody on aluminum transport in
to rat tissues was, however, observed when aluminum was infused in the
citrate form. Therefore, transport of aluminum and gallium into tissu
es is not similar under all conditions. Transport of each metal occurs
into all tissues in the presence of antitransferrin receptor antibody
. The potential for such transport is much greater in the case of gall
ium. Transport of aluminum and gallium citrate complexes appears impor
tant especially in the renal cortex and bone.