EVIDENCE THAT GABA AUGMENTATION OF NOREPINEPHRINE RELEASE IS MEDIATEDBY INTERNEURONS

Authors
FIBER JM ETGEN AM
Citation
Jm. Fiber et Am. Etgen, EVIDENCE THAT GABA AUGMENTATION OF NOREPINEPHRINE RELEASE IS MEDIATEDBY INTERNEURONS, Brain research, 790(1-2), 1998, pp. 329-333
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
790
Issue
1-2
Year of publication
1998
Pages
329 - 333
Database
ISI
SICI code
0006-8993(1998)790:1-2<329:ETGAON>2.0.ZU;2-2
Abstract
GABA(A) receptor activation augments stimulated release of H-3-norepin ephrine (NE) in brain slices from female rats. This effect is not bloc ked by acetazolamide or MK-801, indicating that permeability of the GA BA(A) chloride channel to bicarbonate ions and NMDA receptor activatio n do not mediate GABA-induced NE release. Furthermore, GABA augments H -3-NE release from slices, but not from isolated nerve terminals (syna ptosomes), indicating that interneurons mediate GABA effects on H-3-NE release. (C) 1998 Elsevier Science B.V.