SYNTHESIS OF 4-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONES VIA BETA-LACTAM INTERMEDIATES ON THE SOLID-PHASE

Authors
PEI YZ HOUGHTEN RA KIELY JS
Citation
Yz. Pei et al., SYNTHESIS OF 4-AMINO-3,4-DIHYDRO-2(1H)-QUINOLINONES VIA BETA-LACTAM INTERMEDIATES ON THE SOLID-PHASE, Tetrahedron letters, 38(19), 1997, pp. 3349-3352
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
19
Year of publication
1997
Pages
3349 - 3352
Database
ISI
SICI code
0040-4039(1997)38:19<3349:SO4VBI>2.0.ZU;2-1
Abstract
The synthesis of 3,4-dihydro-2(1H)-quinolinones has been accomplished through me rearrangement of beta-lactam intermediates on the solid-pha se. The beta-lactam intermediates were constructed through [2+2] cyclo additions between ketenes and imines on the solid-phase. A library of 4,140 dihydroquinolinones has been produced using this synthetic proce ss. (C) 1997 Elsevier Science Ltd.