SOLID-PHASE SYNTHESIS OF FUSED BICYCLIC AMINO-ACID DERIVATIVES VIA INTRAMOLECULAR PAUSON-KHAND CYCLIZATION - VERSATILE SCAFFOLDS FOR COMBINATORIAL CHEMISTRY

Solution and solid phase synthetic methods leading to the rapid, stere ocontrolled construction of highly functionalized fused bicyclic amino acid derivatives have been developed. The key step involves a unique application of the intramolecular Pauson-Khand cyclization for the con struction of hexahydro-1H-[2]pyrindinone ring systems. Further modific ations which demonstrate the potential for combinatorial library gener ation are also disclosed. (C) 1997 Published by Elsevier Science Ltd.