ENANTIOMERIC SEPARATION OF RAC-INDOPROFEN BY A BIOCATALYTIC PROCEDURE

Authors
MORRONE R NICOLOSI G PIATTELLI M
Citation
R. Morrone et al., ENANTIOMERIC SEPARATION OF RAC-INDOPROFEN BY A BIOCATALYTIC PROCEDURE, Chirality, 10(4), 1998, pp. 321-324
Citations number
17
Categorie Soggetti
Chemistry Medicinal","Chemistry Analytical","Chemistry Inorganic & Nuclear","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
10
Issue
4
Year of publication
1998
Pages
321 - 324
Database
ISI
SICI code
0899-0042(1998)10:4<321:ESORBA>2.0.ZU;2-2
Abstract
Lipase from Candida antarctica, commercially available immobilised on acrylic resin as Novozym(R) 435, allows for enantioselective esterific ation of racindoprofen (+/-)-1, with methanol in a dioxane-toluene sol vent system. A double esterification process affords methyl ester (-)- (R)-2 in 85% e.e. and enantiopure (+)-(S)-1, both in good chemical yie ld. (C) 1998 Wiley-Liss, Inc.