We report a patient with purely cutaneous Rosai-Dorfman disease (RDD)
who presented with a solitary, asymptomatic plaque on the back of her
left thigh, with characteristic, large histiocytoid cells exhibiting e
mperipolesis histologically. Cutaneous lesions occur in 27% of patient
s with Lymph node involvement in RDD however purely cutaneous disease
has only been reported on 18 previous occasions. The aetiology is unkn
own, although it is thought to be a reactive disorder rather than neop
lastic, possibly an immunological response to an infectious agent.