SOLUBILITY STUDY OF SULFAMETHAZINE AND SULFADIMETHOXINE IN SUPERCRITICAL CARBON-DIOXIDE, FLUOROFORM, AND SUBCRITICAL FREON 134A

Authors
ASHRAFKHORASSANI M COMBS MT TAYLOR LT SCHWEIGHARDT FK MATHIAS PS
Citation
M. Ashrafkhorassani et al., SOLUBILITY STUDY OF SULFAMETHAZINE AND SULFADIMETHOXINE IN SUPERCRITICAL CARBON-DIOXIDE, FLUOROFORM, AND SUBCRITICAL FREON 134A, Journal of chemical and engineering data, 42(3), 1997, pp. 636-640
Citations number
18
Categorie Soggetti
Engineering, Chemical",Chemistry
Journal title
Journal of chemical and engineering data → ACNP
ISSN journal
00219568
Volume
42
Issue
3
Year of publication
1997
Pages
636 - 640
Database
ISI
SICI code
0021-9568(1997)42:3<636:SSOSAS>2.0.ZU;2-#
Abstract
An on-line SFE/HPLC system incorporating a recirculating pump to achie ve efficient mixing under static extraction conditions was developed t o measure the solubility of different analytes in supercritical fluids . To test the system and method, the solubility of anthracene in super critical CO2 was measured and the results were quantitatively similar to those reported previously. The solubilities of neat sulfamethazine (SMZ) and sulfadimethoxine (SDM) were measured in supercritical carbon dioxide, supercritical fluoroform, and subcritical Freon 134A. Result s showed that both drugs have significantly higher solubility in subcr itical Freon 134A than in supercritical fluoroform or CO2.