THE RELATION BETWEEN DE-NOVO ATHEROSCLEROSIS REMODELING AND ANGIOPLASTY-INDUCED REMODELING IN AN ATHEROSCLEROTIC YUCATAN MICROPIG MODEL

Citation
Bjgl. Desmet et al., THE RELATION BETWEEN DE-NOVO ATHEROSCLEROSIS REMODELING AND ANGIOPLASTY-INDUCED REMODELING IN AN ATHEROSCLEROTIC YUCATAN MICROPIG MODEL, Arteriosclerosis, thrombosis, and vascular biology, 18(5), 1998, pp. 702-707
Citations number
24
Categorie Soggetti
Peripheal Vascular Diseas",Hematology
ISSN journal
10795642
Volume
18
Issue
5
Year of publication
1998
Pages
702 - 707
Database
ISI
SICI code
1079-5642(1998)18:5<702:TRBDAR>2.0.ZU;2-S
Abstract
Geometric remodeling in de novo atherosclerosis and in restenosis afte r balloon angioplasty constitutes a change in total arterial circumfer ence that, together with plaque growth or neointima formation, determi nes the lumen of the artery. The heterogeneous nature of arterial obst ructions raises the question of whether early and late outcomes (reste nosis) of angioplasty are affected by the degree and direction of de n ovo atherosclerotic remodeling. This study was designed to assess the relationship between atherosclerotic remodeling and the degree and mec hanism of restenosis after balloon angioplasty. Atherosclerosis was in duced in 27 peripheral arteries of 18 Yucatan micropigs by a combinati on of denudation and atherogenic diet, Balloon angioplasty was perform ed, with serial intravascular ultrasound and quantitative angiography before and after intervention and at 42 days' follow-up. We used the r elative media-bounded area (MBA), defined as the MBA. of the treated s ite divided by the MBA of the reference, before angioplasty as a measu re of remodeling in de novo atherosclerosis and late MBA loss as a mea sure of remodeling after balloon angioplasty, Relative MBA before angi oplasty was not correlated with angiographic and echographic acute gai n after balloon angioplasty (r=.22, P=.28 and r=.14, P=.48) or with la te lumen loss (r=-.05, P=.81 and r=.19, P=.33). No correlation was fou nd between relative MBA and late MBA loss (r=.14 and P=.48). In the at herosclerotic Yucatan micropig, remodeling during de novo atherosclero sis has no relevance for acute gain and late lumen loss after balloon angioplasty. Both the direction and the extent of remodeling after bal loon angioplasty are not related to the direction and extent of remode ling during de novo atherosclerosis.