RELATIONSHIP BETWEEN INSULIN-RESISTANCE AND PARTIALLY OXIDIZED LDL PARTICLES IN HEALTHY, NONDIABETIC VOLUNTEERS

Citation
M. Carantoni et al., RELATIONSHIP BETWEEN INSULIN-RESISTANCE AND PARTIALLY OXIDIZED LDL PARTICLES IN HEALTHY, NONDIABETIC VOLUNTEERS, Arteriosclerosis, thrombosis, and vascular biology, 18(5), 1998, pp. 762-767
Citations number
32
Categorie Soggetti
Peripheal Vascular Diseas",Hematology
ISSN journal
10795642
Volume
18
Issue
5
Year of publication
1998
Pages
762 - 767
Database
ISI
SICI code
1079-5642(1998)18:5<762:RBIAPO>2.0.ZU;2-J
Abstract
This study was performed in 36 healthy volunteers to define the relati onship between plasma concentrations of partially oxidized low density lipoprotein (poxLDL), plasma glucose and insulin responses to oral gl ucose, and steady-state plasma glucose (SSPG) concentrations after a 1 80-minute infusion of somatostatin, insulin, and glucose. The concentr ation of poxLDL was estimated by determining the amount of conjugated dienes formed during in vitro LDL oxidation in the presence or absence of alanine, Under these conditions, the greater the in vitro antioxid ant effect of alanine, the lower the amount of poxLDL that was present in plasma. The results demonstrated that plasma poxLDL concentration was significantly correlated with plasma glucose (r=.53, P<.001) and i nsulin (r=.43, P<.01) responses, SSPG concentrations (r=.53, P<.001), and plasma triglyceride (r=.42, P<.01) and HDL cholesterol (r=-.50, P< .002) concentrations. Furthermore, these relationships persisted when the data were corrected for differences in age, sex, body mass index, and the ratio of waist to hip girth. Of note, there was no correlation between poxLDL and LDL cholesterol concentration. When SSPG was enter ed along with age, sex, body mass index, and waist-to-hip ratio in a m ultiple regression model, SSPG alone was a significant prediction of p oxLDL (r(2)=.37, P<.02). The addition of plasma glucose and insulin re sponses and triglyceride and HDL cholesterol concentrations increased the r(2) to only .47. These results show that the amount of poxLDL in plasma is significantly correlated with insulin resistance (ie, SSPG) and its metabolic consequences.