FORMATION OF RING-SHAPED STRUCTURES ON ERYTHROCYTE-MEMBRANES AFTER TREATMENT WITH BOTULINOLYSIN, A THIOL-ACTIVATED HEMOLYSIN FROM CLOSTRIDIUM-BOTULINUM

Authors
SEKIYA K DANBARA H FUTAESAKU Y HAQUE A SUGIMOTO N MATSUDA M
Citation
K. Sekiya et al., FORMATION OF RING-SHAPED STRUCTURES ON ERYTHROCYTE-MEMBRANES AFTER TREATMENT WITH BOTULINOLYSIN, A THIOL-ACTIVATED HEMOLYSIN FROM CLOSTRIDIUM-BOTULINUM, Infection and immunity, 66(6), 1998, pp. 2987-2990
Citations number
35
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
6
Year of publication
1998
Pages
2987 - 2990
Database
ISI
SICI code
0019-9567(1998)66:6<2987:FORSOE>2.0.ZU;2-8
Abstract
Damage to erythrocyte membranes by botulinolysin (BLY) was studied by electron microscopy, which revealed ring-shaped structures with inner diameters and widths of approximately 32 and 6.7 nm, respectively. BLY bound to membranes at 0 degrees C, but subsequent treatment with glut araldehyde prevented ring formation during further incubation at 37 de grees C. Zn2+ ions inhibited ring formation but not binding of BLY to membranes.