THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE - AFFINITY AND SELECTIVITY RELATIONSHIP STUDY OF POTENT N4-SUBSTITUTED ARYLPIPERAZINE 5-HT1(ALPHA) RECEPTOR ANTAGONISTS

Authors
MENZIANI MC DEBENEDETTI PG KARELSON M
Citation
Mc. Menziani et al., THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE - AFFINITY AND SELECTIVITY RELATIONSHIP STUDY OF POTENT N4-SUBSTITUTED ARYLPIPERAZINE 5-HT1(ALPHA) RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry, 6(5), 1998, pp. 535-550
Citations number
15
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
5
Year of publication
1998
Pages
535 - 550
Database
ISI
SICI code
0968-0896(1998)6:5<535:TDIQS->2.0.ZU;2-B
Abstract
The ability of ad hoc defined size and shape descriptors and theoretic al descriptors derived on a single structure to give poweful interpret ative and predictive QSAR models has been compared and evaluated with respect to the quality of the pharmacological data available for a ser ies of structurally diverse 5-HT1(A) receptor antagonists, displaying selectivity towards the alpha 1-adrenergic receptor. (C) 1998 Elsevier Science Ltd. All rights reserved.