SYNTHESIS AND RADIOPROTECTIVE EFFECTS OF ADAMANTYL SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES

A series of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid die sters substituted at the N-1 and/or C-4 positions of the dihydropyridi ne ring was synthesized. The in vit:ro cytotoxicity and in vitro and i n vivo radioprotective efficacy of these agents were evaluated in Chin ese hamster (V-79) cells and CD2F1 male mice, respectively. Compounds with at least one adamantyl substituent afforded better radioprotectio n than those without this substituent. Substitution of an aromatic rin g at the C-4 position of the dihydropyridine :ring did not enhance the radioprotectant action of the compounds. (C) 1998 Published by Elsevi er Science Ltd. All rights reserved.