RETENTION, HIV RISK, AND ILLICIT DRUG-USE DURING TREATMENT - METHADONE DOSE AND VISIT FREQUENCY

Objectives. This study examined two major methadone treatment factors, visit frequency and methadone dose, posited to be important in reduci ng intravenous drug use and human immunodeficiency virus (HIV) transmi ssion. Methods. One hundred fifty opiate-dependent subjects randomly a ssigned to four groups received 50 or 80 mg of methadone and attended a clinic 2 or 5 days per week. Results. Survival analysis indicated hi gher dropout rates for groups having five vs two visits per week (chi( 2) [1] = 7.76). Higher proportions of opiate-positive results on urine screens were associated with lower methadone doses (F [1,91] = 4.74). Conclusions. Receiving take-home doses early in treatment enhanced tr eatment retention. The 50-mg dose combined with five visits per week p roduced the worst outcome. Fewer visits enhanced retention at 50 mg, b ut opiate use rates were higher at this dose than they were for either 80-mg group. The HIV infection rate at entry was 9%. No subjects sero converted during the study. Risk behaviors for acquired immunodeficien cy syndrome declined over time regardless of group/dose assignment. Th ese results have Important implications for modification of regulatory and clinic policy changes.