HISTORIES OF SUBSTANCE USE AND RISK BEHAVIOR - PRECURSORS TO HIV SEROCONVERSION IN HOMOSEXUAL MEN

Objectives. This study compared history of substance use and episodic use in terms of HIV seroconversion. Methods. A sample of 337 baseline HIV-negative gay men was followed for-ti years. Bivariate and survival analyses were used to compare 39 converters with nonconverters on sub stance use behaviors. Results. Seroconverters were consistently more l ikely to report use of marijuana, nitrite inhalants, amphetamines, and cocaine than nonconverters. Consistent use of nitrite inhalants and a mphetamines increases the relative risk of seroconversion, while episo dic use does not. Both patterns of cocaine use increase seroconversion risk. Conclusions. There are three potential mechanisms for an increa sed risk of conversion due to consistent substance use.