Urinary tract infections (UTIs) usually occur as a consequence of colo
nization of the periurethral area by a virulent organism that subseque
ntly gains access to the bladder During the first few months of life,
uncircumcised male infants are at increased risk for UTIs, but thereaf
ter UTIs predominate in females. An important risk factor for UTIs in
girls is antibiotic therapy, which disrupts the normal periurethral fl
ora and fosters the growth of uropathogenic bacteria. Another risk fac
tor is voiding dysfunction. currently the most effective intervention
for preventing recurrent UTIs in children is the identification and tr
eatment of voiding dysfunction. Imaging evaluation of the urinary trac
t following a UTI should be individualized, based on the child's clini
cal presentation and on clinical judgment. Both bladder and upper urin
ary tract imaging with ultrasonography and a voiding cystourethrogram
should be obtained in an infant or child with acute pyelonephritis. Im
aging studies may not be required, however, in older children with cys
titis who respond promptly to treatment.