Al. Killam et al., LACK OF BIOEFFECTS OF ULTRASOUND ENERGY AFTER INTRAVENOUS ADMINISTRATION OF FS069 (OPTISON) IN THE ANESTHETIZED RABBIT, Journal of ultrasound in medicine, 17(6), 1998, pp. 349-356
Citations number
26
Categorie Soggetti
Acoustics,"Radiology,Nuclear Medicine & Medical Imaging
The current study was designed to provide a sensitive in vivo model to
maximize the potential bioeffects (measured by hemolysis) of B-mode u
ltrasound energy in combination with FS069 (Optison). B-mode ultrasoun
d energy was delivered to anesthetized male New Zealand white rabbits
with a phased array 5 MHz transducer on a Hewlett-Packard Sonos 1500 u
ltrasonograph, with transmit level set to maximum (40 dB, approx 135 W
/cm(2)). FS069 (Optison), latex particles in human albumin, or human a
lbumin alone (vehicle) was infused via an ear vein at 0.6 mL/kg. No st
atistically significant changes were noted in serum free hemoglobin or
lactate dehydrogenase either over time or between groups.