LACK OF BIOEFFECTS OF ULTRASOUND ENERGY AFTER INTRAVENOUS ADMINISTRATION OF FS069 (OPTISON) IN THE ANESTHETIZED RABBIT

The current study was designed to provide a sensitive in vivo model to maximize the potential bioeffects (measured by hemolysis) of B-mode u ltrasound energy in combination with FS069 (Optison). B-mode ultrasoun d energy was delivered to anesthetized male New Zealand white rabbits with a phased array 5 MHz transducer on a Hewlett-Packard Sonos 1500 u ltrasonograph, with transmit level set to maximum (40 dB, approx 135 W /cm(2)). FS069 (Optison), latex particles in human albumin, or human a lbumin alone (vehicle) was infused via an ear vein at 0.6 mL/kg. No st atistically significant changes were noted in serum free hemoglobin or lactate dehydrogenase either over time or between groups.