PROCESS IMPROVEMENT IN THE PRODUCTION OF A PHARMACEUTICAL INTERMEDIATE USING A REACTION CALORIMETER FOR STUDIES ON THE REACTION-KINETICS OFAMINATION OF A BROMOPROPYL COMPOUND

A synthetic process to produce a pharmaceutical intermediate, [3-(dime thylamino)propyl]triphenylphosphonium bromide (1), was established in the laboratory. Process safety evaluations did not show any severe pro blems. In order to scale up to plant scale, we simulated the reaction for both heat production and byproduct production profiles with kineti c parameters. The kinetic parameters were obtained by laboratory exper iments and reaction calorimeter measurements. Under the established co nditions, the production operated in a safe manner with high quality.