INDEPENDENT SYNTHESIS AND FATE STUDIES OF IMPURITIES IN-PROCESS INTERMEDIATES OF THE ANTI-AIDS DRUG D4T

Authors
REDDY JP REID JG RENNER DA QUINLAN SL WEAVER DG CHEN BC STARK DR GAO Q
Citation
Jp. Reddy et al., INDEPENDENT SYNTHESIS AND FATE STUDIES OF IMPURITIES IN-PROCESS INTERMEDIATES OF THE ANTI-AIDS DRUG D4T, Organic process research & development, 2(3), 1998, pp. 203-207
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
3
Year of publication
1998
Pages
203 - 207
Database
ISI
SICI code
1083-6160(1998)2:3<203:ISAFSO>2.0.ZU;2-4
Abstract
Impurities in isolated intermediates in a process to prepare d4T were identified, independently synthesized, and then taken through the proc ess to determine their ultimate fate. Some of the products from these fate studies were also independently synthesized and used in the valid ation of impurity assay methods.