M. Ugur et al., PROPHYLACTIC VASOPRESSIN DURING LAPAROSCOPIC SALPINGOTOMY FOR ECTOPICPREGNANCY, The Journal of the American Association of Gynecologic Laparoscopists, 3(3), 1997, pp. 365-368
Study Objective. To evaluate the safety and efficacy of prophylactic m
esosalpingeal vasopressin injection for hemostasis during laparoscopic
salpingotomy for ectopic pregnancy. Design. Prospective, randomized c
linical study. Setting. Reproductive endocrinology and endoscopic surg
ery clinic of a tertiary care hospital. Patients. Forty women with ect
opic pregnancy. Interventions. Laparoscopic linear salpingotomy was at
tempted with prophylactic mesosalpingeal dilute vasopressin injection
in 20 patients (study group), and without vasopressin in 20 patients (
control group). The two groups were similar with regard to age, size o
i ectopic pregnancy, gestational age, and initial B-hCG values. A mult
ipuncture operative laparoscopy technique was used in all cases and bi
polar electrocoagulation was used for hemostasis. Measurements and Mai
n Results. The operating time was significantly shorter and the need f
or electrocoagulation was significantly less in the study than in the
control group (p<0.05). Laparoscopic salpingotomy was performed succes
sfully in 85% of study group patients compared with 70% of controls (p
>0.05). Postoperative hysterogram revealed patency oi the affected tub
e in 76.5% of women in the study group compared with 57.1% of controls
(p>0.05). Possible complications of vasopressin, such as hypertension
, bradycardia, and delayed bleeding, did not occur in any patient. Con
clusions. Vasopressin use reduces both operating time and the need for
electrocoagulation for hemostasis, which can have undesirable effects
on the tube. Vasopressin was not associated with side effects in this
relatively small sample.