SYNTHESIS AND CENTRAL-NERVOUS-SYSTEM STIMULANT ACTIVITY OF CAMPHOR-1,2,4-BENZOTRIAZINES FUSED WITH 5-MEMBERED AND 6-MEMBERED HETEROCYCLES

Authors
NAGAI S UEDA T TAKAMURA M NAGATSU A MURAKAMI N SAKAKIBARA J
Citation
S. Nagai et al., SYNTHESIS AND CENTRAL-NERVOUS-SYSTEM STIMULANT ACTIVITY OF CAMPHOR-1,2,4-BENZOTRIAZINES FUSED WITH 5-MEMBERED AND 6-MEMBERED HETEROCYCLES, Journal of heterocyclic chemistry, 35(2), 1998, pp. 293-296
Citations number
2
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
35
Issue
2
Year of publication
1998
Pages
293 - 296
Database
ISI
SICI code
0022-152X(1998)35:2<293:SACSAO>2.0.ZU;2-Z
Abstract
Novel camphor-1,2,4-triazines fused with imidazole 2-3, thiadiazole 4, 1,2,4-triazole 7, pyrimidine 9-13 and 1,3,5-triazine 14, were synthes ized starting from 5,6,7,8-tetrahydro-5,8-methano-1,2,4-benzotriazine 1. Evaluation of central nervous system stimulant activity demonstrate d that the presence of a N-N group at C-3 position of 1,2,4-benzotriaz ine will be essential for the activity.