SYNTHESIS OF SEVERAL DEOXY ANALOGS OF PANCRATISTATIN

N-Acetylated 1,4,7- and 3,4,7-trideoxypancratistatin analogues 10 and 13 were synthesised from partially saturated phenanthridinones, 6 and 7, respectively via epoxidation and trans opening of the epoxides, Com pounds 16 and 17, cis analogues of 13 were also synthesised from 7 via cis dihydroxylation with catalytic osmium tetroxide and N-methylmorph oline N-oxide. The stereoisomers obtained were separated by column chr omatography after protection of the hydroxyl groups. The products synt hesised are characterised satisfactorily by ir, nmr, ms and microanaly sis data and are expected to possess anticancer or antiviral activity.