METALATION OF T-BUTYL SULFOXIDES, SULFONES AND SULFONAMIDES OF PYRIDAZINE AND PYRAZINE - METALATION OF DIAZINES - XX

In the pyridazine series, the use of tert-butylsulfinyl and tert-butyl sulfonyl as ortho directing groups for metalation has been tested. Var ious functionalized products were obtained in good yields. In the case of 3-tert-butylsulfinyl-6-methoxypyridazine the metalation was regios elective in ortho to the sulfinyl group. The metalation of 2-tert-buty lsulfinyl and 2-tert-butylsulfonylpyrazine gave low to moderate yields . Synthesis of diazinesulfonamides were improved and the metalation of N-tert-butylsulfonamidopyrazine was achieved.