THE USE OF THYROID SUPPLEMENTS TO AUGMENT ANTIDEPRESSANT MEDICATION

Despite methodological flaws that limit conclusions, a considerable da tabase documents the efficacy of triiodothyronine (T-3) as an augmenta tion strategy for response to various classes of antidepressants. One study suggests that T-3 and lithium are of comparable efficacy in anti depressant nonresponders. No clear biochemical or clinical predictors of preferential response to T-3 have been found. The role of T-3 augme ntation requires further evaluation, especially with regard to dose an d duration.