NO SEROTONIN 5-HT2A RECEPTOR DENSITY ABNORMALITY IN THE CORTEX OF SCHIZOPHRENIC-PATIENTS STUDIED WITH PET

To investigate putative abnormalities of cortical 5-HT2A receptor dens ity in schizophrenia, we used positron emission tomography and [F-18]s etoperone, a high-affinity 5-HT2A receptor radioligand, in 14 neurolep tic-free or -naive schizophrenic patients and in 15 normal controls. N o significant difference between the groups was observed in the whole or regional cortical binding potential of [F-18]setoperone, indicating an absence of major 5-HT2A receptor cortical density abnormalities in schizophrenics. (C) 1998 Elsevier Science B.V. All rights reserved.