PREDOMINANT IMPLICATION OF IL-5 IN ACUTE EOSINOPHILIC PNEUMONIA - COMPARISON WITH CHRONIC EOSINOPHILIC PNEUMONIA

Background: Acute eosinophilic pneumonia (AEP) is a rare disease with unknown etiology. To examine pathophysiology of AEP we measured the ce ll number of eosinophils and eosinophil active cytokines in the periph eral blood and bronchoalveolar lavage fluid (BALF) of AEP patients and compared the levels with those measured in chronic eosinophilic pneum onia (CEP) patients. Methods: Cell number of eosinophils in peripheral blood and BALE from patients with AEP (n = 3) and CEP (n = 3) were me asured. Eosinophil active cytokines in serum and BALF from the patient s were measured using ELISA. Results: Eosinophil cell number in periph eral blood was 274-1,377/mm(3) in AEP and 526-2,500/mm(3) in CEP. The percentages of BALF eosinophils were high in AEP and CEP. Eosinophilia disappeared after methylprednisolone pulse therapy (1 g for 3 days) i n AEP, however the cell number of eosinophils gradually increased afte r methylprednisolone pulse therapy and then spontaneously decreased to within normal range without any further medication. The concentration s of IL-5 in AEP were very high in serum and in BALE however the conce ntrations in CEP were low in serum and BALE Conclusion: AEP is a disea se in which eosinophil active cytokine IL-5 is predominantly involved; CEP is not. The factors involving eosinophil infiltration to inflamma tory loci differ between AEP and CEP.