2 EPIMERIC PAIRS OF C-4-ACETYL ANNONACEOUS ACETOGENINS FROM GONIOTHALAMUS-DONNAIENSIS

Further studies on the roots of Goniothalamus donnaiensis Finet et Gag nap (Annonaceae) led to the isolation of two pairs of Annonaceous acet ogenins, donnaienin C (1) and 34-epi-donnaienin C (1'), donnaienin D ( 2) and 34-epi-donnaienin D (2'), containing a rare gamma-hydroxymethyl -gamma-lactone moiety and a C-4-acetoxy group. Their structures were e lucidated by spectral data and chemical derivatization. Preliminary ph armacological tests showed that the mixture of donnaienin C (1) and 34 -epi-donnaienin C (1') inhibited human hepatoma (Bel) cell lines in vi tro (IC50, 7.1 mu g/ml).