LUPEOL IS THE CYTOTOXIC PRINCIPLE IN THE LEAF EXTRACT OF DENDROPANAX CF. QUERCETI

Authors
MORIARITY DM HUANG J YANCEY CA ZHANG P SETZER WN LAWTON RO BATES RB CALDERA S
Citation
Dm. Moriarity et al., LUPEOL IS THE CYTOTOXIC PRINCIPLE IN THE LEAF EXTRACT OF DENDROPANAX CF. QUERCETI, Planta medica, 64(4), 1998, pp. 370-372
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
4
Year of publication
1998
Pages
370 - 372
Database
ISI
SICI code
0032-0943(1998)64:4<370:LITCPI>2.0.ZU;2-Z
Abstract
The crude ethanol extract from the leaves of Dendroponax cf. querceti (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-GZ, A-431, and H-411E tumor cell lines. The active compone nt has been isolated by activity-directed separation and identified by H-1-and C-13-NMR spectroscopy as the triterpene lupeol. The mechanism of cytotoxic activity of lupeol has been determined to be inhibition of topoisomerase II.