INVESTIGATION OF INTERACTIONS BETWEEN ANTIMICROBIAL AGENTS AND BACTERIAL BIOFILMS USING ATTENUATED TOTAL-REFLECTION FOURIER-TRANSFORM INFRARED-SPECTROSCOPY

Authors
SUCI PA VRANY JD MITTELMAN MW
Citation
Pa. Suci et al., INVESTIGATION OF INTERACTIONS BETWEEN ANTIMICROBIAL AGENTS AND BACTERIAL BIOFILMS USING ATTENUATED TOTAL-REFLECTION FOURIER-TRANSFORM INFRARED-SPECTROSCOPY, Biomaterials, 19(4-5), 1998, pp. 327-339
Citations number
91
Categorie Soggetti
Materials Science, Biomaterials","Engineering, Biomedical
Journal title
Biomaterials → ACNP
ISSN journal
01429612
Volume
19
Issue
4-5
Year of publication
1998
Pages
327 - 339
Database
ISI
SICI code
0142-9612(1998)19:4-5<327:IOIBAA>2.0.ZU;2-Y
Abstract
Biomaterial-centred infections are often difficult to treat. An impair ed immune response, acute inflammatory reactions and the presence of r ecalcitrant attached microorganisms are ail contributing factors. A br ief review of the role of attached bacteria in biomaterial-centred inf ections is presented. Two major hypotheses which. may explain the reca lcitrance of biofilms to antimicrobial agents are discussed. The analy tical capabilities of attenuated total reflection Fourier transform in frared (ATR/FTIR) spectroscopy for providing information on both trans port of an antimicrobial agent to bacteria embedded in the biofilm and interactions between an antimicrobial agent and biofilm components ar e described. (C) 1998 Elsevier Science Ltd. All rights reserved.