PRO AND ANTICONVULSANT EFFECTS OF XYLAZINE ON CONVULSION MODELS IN RODENTS

Authors
SPINOSA HD GORNIAK SL PALERMONETO J BERNARDI MM SPINOSA FR
Citation
Hd. Spinosa et al., PRO AND ANTICONVULSANT EFFECTS OF XYLAZINE ON CONVULSION MODELS IN RODENTS, Veterinary and human toxicology, 36(1), 1994, pp. 12-14
Citations number
13
Categorie Soggetti
Toxicology,"Veterinary Sciences
Journal title
Veterinary and human toxicology → ACNP
ISSN journal
01456296
Volume
36
Issue
1
Year of publication
1994
Pages
12 - 14
Database
ISI
SICI code
0145-6296(1994)36:1<12:PAAEOX>2.0.ZU;2-0
Abstract
Pretreatment of mice with 30 mg xylazine/kg ip protected against convu lsions induced by amphetamine, but it intensified pentylenetetrazole- and strychnine-induced seizures. Xylazine pretreatment also protected rats against electroshock-induced convulsions. These findings support a noradrenergic mechanism being involved in the proconvulsant and/or a nticonvulsant effects of xylazine.