NIFEDIPINE IN RAT-LIVER CIRRHOSIS

Authors
CUTRIN C MENINO J CARBALLO C PARAFITA MA PEREZBECERRA E BARRIO E
Citation
C. Cutrin et al., NIFEDIPINE IN RAT-LIVER CIRRHOSIS, Veterinary and human toxicology, 36(1), 1994, pp. 14-16
Citations number
18
Categorie Soggetti
Toxicology,"Veterinary Sciences
Journal title
Veterinary and human toxicology → ACNP
ISSN journal
01456296
Volume
36
Issue
1
Year of publication
1994
Pages
14 - 16
Database
ISI
SICI code
0145-6296(1994)36:1<14:NIRC>2.0.ZU;2-E
Abstract
Rat liver cirrhosis induced by CCl4+ethanol was employed to assess the effectiveness of nifedipine in reducing liver injury. Nifedipine redu ced the severity of hepatocellular necrosis, significantly decreased M allory bodies (p < 0.01), decreased polymorphonuclear inflammatory inf iltrate (p < 0.05) and reduced perivenular fibrosis. Plasma lactic aci d levels were significantly increased in the CCl4+ethanol group (p < 0 .01). Lactacidaemia remained at normal values when the calcium antagon ist blocker was employed. Nifedipine did not significantly alter the i ncidence of cirrhosis in this experimental model.