ACROCYANOSIS INDUCED BY INTERFERON ALPHA(2A)

Authors
CAMPOVOEGELI A ESTRACH T MARTI RM COROMINAS N TUSET M MASCARO JM
Citation
A. Campovoegeli et al., ACROCYANOSIS INDUCED BY INTERFERON ALPHA(2A), Dermatology, 196(3), 1998, pp. 361-363
Citations number
22
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Dermatology → ACNP
ISSN journal
10188665
Volume
196
Issue
3
Year of publication
1998
Pages
361 - 363
Database
ISI
SICI code
1018-8665(1998)196:3<361:AIBIA>2.0.ZU;2-T
Abstract
A 56-year-old woman with mycosis fungoides developed acrocyanosis each time treatment with interferon alpha(2a) was started. Acrocyanosis di sappeared after discontinuing therapy. Immunological study performed w hile acrocyanosis was present showed elevated antinuclear antibody (AN A) titers and circulating immune-complex levels. Long-term interferon treatment has been related to autoimmune side effects. Raynaud's pheno menon has been observed in patients undergoing interferon treatment as sociated with elevated ANA titers, to cryoglobulinemia or to arterial occlusion. Acrocyanosis has never before been described as side effect in patients undergoing this treatment. We believe that our patient's acrocyanosis must be considered a side effect of interferon.