HOMOCYSTEINE, 5,10 METHYLENETETRAHYDROFOL ATE REDUCTASE AND DEEP VENOUS THROMBOSIS - STUDY AMONG 120 PATIENTS IN INTERNAL-MEDICINE

Background. - In the last few years, the association of deep vein thro mbosis with frequent biological risk factors and genetic polymorphisms has significantly modified the field of venous thrombosis. In this st udy, we measured plasma homocystein levels and tested the C677T methyl entetrahydrofolate reductase (MTHFR) mutation. Patients and methods. - Plasma homocystein levels and test for C677T MTHFR mutation were perf ormed in 120 consecutive patients with objectively diagnosed deep vein thrombosis, and in 120 controls. Results. - We found a strong associa tion between hyperhomocysteinemia and thrombosis (odd ratio: 2.43 IC 9 5% [1.27-4.71]). Conversely the C677T MTHFR gene polymorphism is only associated with hyperhomocysteinemia but not associated with thrombosi s. Conclusion. - This is a preliminary study to the ongoing internatio nal multicentric study of SNFMI (Societe nationale francaise de medeci ne interne) concerning hyperhomocysteinemia and venous thrombosis. (C) 1998, Elsevier, Paris.