Two rare cases of mesenteric fibromatosis are presented, The first pat
ient had a right upper quadrant mass and colicky abdominal pain. The t
umor originated from the mesentery of the colon and it infiltrated the
gallbladder, cystic duct, and the liver. The second patient had sever
e hematemesis and melena, The origin of the tumor, which infiltrated 3
/4 part of the stomach, the gastrohepatic ligament, the first part of
the duodenum, and the liver could not be determined. In the first pati
ent, partial colectomy and cholecystectomy were performed and the live
r lesion was completely excised. The second patient underwent subtotal
gastrectomy and left lobectomy of the liver. The first part of the du
odenum was excised. Gastrojejunostomy was performed. No recurrence was
recorded in either patients during 16 and 13 months follow-up, respec
tively. In this report, diagnostic aids, differential diagnosis and tr
eatment of this rare disease are discussed.