The aerial parts of Tanacetum argenteum subsp. canum var, canum (Compo
sitae) afforded six guaianolides, five of them (2-6) being new: flabel
lin (1), epoxyflabellin (2), Delta(3(4))-15-oxo-flabellin (3), Delta(3
(4))-15-hydroxydihydroflabellin (4), 11 alpha-dihydroflabellin (5), an
d 11 beta-dihydroflabellin (6). The structures of the compounds were e
lucidated by spectral methods including NMR (H-1 NMR, COSY, APT, HETCO
R, NOE) and X-ray diffraction, as well as by some chemical reactions.