ANTIVIRAL PHENYLPROPANOID GLYCOSIDES FROM THE MEDICINAL PLANT MARKHAMIA-LUTEA

Three new phenylpropanoid glycosides, named luteoside A (3), luteoside B (4), and luteoside C (5), were isolated together with the known com pounds verbascoside (1) and isoverbascoside (2) from the roots of the medicinal plant Markhamia lutea. The structures of the new compounds w ere determined to be 1-O-(3,4-dihydroxyphenyl)ethyl ha-L-rhamnopyranos yl(1-->3)-4-O-caffeoyl-6-acetyl- beta-D-glucopyranoside, 1-O-(3,4-dihy droxyphenyl)ethyl anosyl(1-->3)-6-O-caffeoyl-beta-D-glucopyranoside, a nd 1-O-(3,4-dihydroxyphenyl)ethyl anosyl(1-->3)-6-O-feruloyl-beta-D-gl ucopyranoside, respectively, on the basis of chemical and spectroscopi c data. All five phenylpropanoid glycosides exhibited potent in vitro activity against respiratory syncytial virus.