ANTIFUNGAL AMIDE FROM LEAVES OF PIPER HISPIDUM

Authors
ALECIO AC BOLZANI VD YOUNG MCM KATO MJ FURLAN M
Citation
Ac. Alecio et al., ANTIFUNGAL AMIDE FROM LEAVES OF PIPER HISPIDUM, Journal of natural products, 61(5), 1998, pp. 637-639
Citations number
13
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
5
Year of publication
1998
Pages
637 - 639
Database
ISI
SICI code
0163-3864(1998)61:5<637:AAFLOP>2.0.ZU;2-H
Abstract
Bioactivity-guided fractionation of a CH2Cl2 extract from leaves of Pi per hispidum (Piperaceae) yielded a new pyrrolidine amide, ',4'-methyl enedioxyphenyl)-2(Z),4(Z)-heptadienoyl] pyrrolidine 1, in addition to two known amides ethylenedioxyphenyl)-2(E)-pentadienoyl]pyrrolidine an d ioxy-6'-methoxyphenyl)-2(Z)-propenoyl]pyrrolidine. The structure of compound 1 was elucidated by interpretation of spectral data, includin g ES-MS. Compound 1 showed antifungal activity against Cladosporium sp haerospermum.