RADICAL SCAVENGING ACTIVITY OF ACER NIKOENSE MAXIM - EXTRACT

The effect of hot water and alkaline extracts of Acer nikoense Maxim. on the radical intensity of sodium ascorbate, superoxide anion (O-2(-) )(produced by hypoxanthine-xanthine oxidase reaction) and hydroxyl rad ical (. OH)(generated by Fenton reaction) was investigated using ESR s pectroscopy. All these extracts produced radical(s) under alkaline con ditions and enhanced the radical intensity of sodium ascorbate. Among these fractions, Fr. I showed the highest stimulation effect, which co incided with its higher degradation rate and capacity to enhance the c ytotoxic activity of ascorbate. These fractions also dose-dependently reduced the radical intensity of O-2(-) and . OH. The present study de monstrates that Acer nikoense Maxim, extracts potentiate both radical intensity and apoptosis-inducing activity of ascorbate.