NM23-H1 AND NM23-H2 GENE-EXPRESSION IN HUMAN RENAL TUMORS

The two nm23 genes, nm23-H1 and nm23-H2, are implicated in the metasta tic process and tumor progression in some human tumors. Until now no d ata exist about nm23 expression in the different types of human renal tumours. To investigate if the nm23 genes play a central role in the p rogression of renal tumors, we have examined nm23-H1 and nm23-H2 gene expression using Northern-blot analysis and immunohistochemistry. We a nalysed clear cell type RCC, chromophilic RCC, chromophobic RCC, colle cting duct type RCC and renal oncocytomas. Our results indicate that t he nm23 genes do not play a central role in the prognosis of renal cel l carcinoma in the analysed tumors.