SUCCESSFUL TREATMENT OF RHINOCEREBRAL MUCORMYCOSIS BY A COMBINATION OF AGGRESSIVE SURGICAL DEBRIDEMENT AND THE USE OF SYSTEMIC LIPOSOMAL AMPHOTERICIN-B AND LOCAL THERAPY WITH NEBULIZED AMPHOTERICIN - A CASE-REPORT

A case of mucormycosis involving the nose and paranasal sinuses in a 5 5-year-old man with recently diagnosed acute promyelocytic leukaemia i s reported. It was successfully treated with a combination of aggressi ve surgical debridement and systemic amphotericin B. In addition, loca l nebulized amphotericin B was used as an adjunct to therapy. We belie ve this is only the second documented use of nebulized amphotericin in the management of sinonasal mucormycosis. The need for a high index o f suspicion and early aggressive management is emphasized.