ANCA-POSITIVE LUPUS-ERYTHEMATOSUS PROFUND US - SUCCESSFUL THERAPY WITH LOW-DOSE DAPSONE

A 44-year-old male patient with lupusery-thematosus profundus (lupus p anniculitis) (LEP) of the right cheek/infraorbital region presented as a recurrent swelling. He had only anti-neutrophil-cytoplasmic antibod ies (ANCA),which have not been previously described in association wit h LEP. There was no indication of systemic lupus erythematosus. While chloroquine produced no benefits, the skin lesions promptly cleared wi th dapsone. Step by step we reduced dapsone to a final dose of 50-75 m g per week. The ANCA titer decreased in parallel to the clinical impro vement.