TRANSLOCATION (3-16)(Q27-P11) IN A PATIENT WITH DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH THE BCL-6 GENE REARRANGEMENT

Authors
ICHINOHASAMA R MIURA I SHISHIDO T MATSUMOTO K SHIMIZU Y MIKI T DECOTEAU JF KADIN ME OOYA K
Citation
R. Ichinohasama et al., TRANSLOCATION (3-16)(Q27-P11) IN A PATIENT WITH DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH THE BCL-6 GENE REARRANGEMENT, Cancer genetics and cytogenetics, 103(2), 1998, pp. 133-139
Citations number
51
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
103
Issue
2
Year of publication
1998
Pages
133 - 139
Database
ISI
SICI code
0165-4608(1998)103:2<133:T(IAPW>2.0.ZU;2-W
Abstract
A patient with B-cell lineage diffuse large-cell lymphoma carrying the t(3;16)(q27;pll) and BCL-6 rearrangement is described. Cytogenetic st udies showed )(q27;p11.2)[11]/46,idem,add(18)(q21)[7]/46,XY[2]. The ch romosomal translocation involving the 3q27 locus was associated with t he BCL-6 gene rearrangement identified by Southern blot analysis. This case involved systemic lymph nodes, as large as 3 cm in diameter, bil aterally in neck, axilla, and inguinal regions. The patient obtained c omplete remission with chemotherapy. (C) Elsevier Science Inc., 1998.