DISSEMINATED INTRAVASCULAR COAGULATION IN ACUTE MONOCYTIC LEUKEMIA OFA DOG

Contrary to what is the case for human beings no investigations on the haemostatic system in dogs suffering from acute leukaemia are availab le until now. In this dog with acute monocytic leukaemia described her e - besides a distinct thrombocytopenia essentially in consequence of bone marrow infiltration by blast cells - diminution of the activity o f various individual coagulation factors as well as antithrombin ill, protein C, plasminogen and alpha(2)-plasmin inhibitor was found. The c learly increased concentrations of soluble fibrin and fibrin(ogen) deg radation products indicated that disseminated intravascular coagulatio n and reactive hyperfibrinolysis are main causes for the loss of activ ity of different haemostatic components.