Objective: To test the effectiveness of a four-item prenatal-alcohol-u
se, self-administered screening questionnaire that asks about toleranc
e to alcohol, being annoyed by other's comments about drinking, attemp
ts to cut down, and having a drink first thing in the morning (''eye-o
pener'') (T-ACE) in an ethnically and socioeconomically diverse sample
. Methods: Two hundred fifty T-ACE-positive and 100 T-ACE-negative wom
en completed a comprehensive assessment of their alcohol use after ini
tiating prenatal care at the Brigham and Women's Hospital in Boston, M
assachusetts. This comprehensive assessment, which included the Alcoho
l Use Disorders Identification Test and the Short Michigan Alcoholism
Screening Test as comparisons to the T-ACE, generated three criterion
standards: Diagnostic and Statistical Manual of Mental Disorders, Thir
d, Ed., Revised (DSM-III-R), lifetime alcohol diagnoses, risk drinking
(regularly having more than one fluid ounce of alcohol per drinking d
ay before pregnancy), and current drinking. Results: T-ACE-positive pr
egnant women were more likely than T-ACE-negative women to satisfy DSM
-III-R criteria for lifetime alcohol diagnoses (40% versus 14%, P < .0
01) and risk drinking (39% versus 8%, P < .001) and to have current al
cohol consumption (43% versus 13%, P < .001). In contrast, obstetric s
taff members documented only 33 (9%) women as using alcohol at any tim
e, even though nearly all subjects (96%) were asked about drinking upo
n initiation of prenatal care. Conclusion: The T-ACE was the most sens
itive screen for lifetime alcohol diagnoses, risk drinking, and curren
t alcohol consumption. It outperformed obstetric staff assessment of a
ny alcohol use by pregnant women enrolled in the study. (C) 1998 by Th
e American College of Obstetricians and Gynecologists.