SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS, PART6 - HYDROXYPROPYL-BETA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT

Authors
LIN BC ZHU XF EPPERLEIN U SCHWIERSKOTT M SCHLUNK R KOPPENHOEFER B
Citation
Bc. Lin et al., SEPARATION OF ENANTIOMERS OF DRUGS BY CAPILLARY ELECTROPHORESIS, PART6 - HYDROXYPROPYL-BETA-CYCLODEXTRIN AS CHIRAL SOLVATING AGENT, HRC. Journal of high resolution chromatography, 21(4), 1998, pp. 215-224
Citations number
43
Categorie Soggetti
Chemistry Analytical
Journal title
HRC. Journal of high resolution chromatography → ACNP
ISSN journal
09356304
Volume
21
Issue
4
Year of publication
1998
Pages
215 - 224
Database
ISI
SICI code
0935-6304(1998)21:4<215:SOEODB>2.0.ZU;2-E
Abstract
Following an extended screening project, 86 racemic drugs were investi gated by capillary zone electrophoresis in the presence of the chiral solvating agent (CSA) hydroxypropyl-beta-cyclodextrin. A total of 42 d rugs out of 86 tested was thereby separated into enantiomeric pairs. S tatistical analysis of the numerous experiments performed un der ident ical conditions reveals a loose correlation of the migration separatio n factor (alpha(m)) with the migration retardation factor (R-m). For a subset of 23 drugs, a drop in the concentration of the CSA was also s tudied, showing the way to further optimization.