NONINVASIVE GLUCOSE MONITORING IN-VIVO WITH AN OPTICAL HETERODYNE POLARIMETER

An amplitude-sensitive optical heterodyne polarimeter was set up to mo nitor noninvasively the aqueous glucose concentration in a rabbit's ey e. A Zeeman laser in conjunction with a Glan-Thompson analyzer was use d to generate an optical heterodyne signal. The amplitude of the heter odyne signal linearly related to the optical rotation angle of the aqu eous glucose. The concentration of the aqueous glucose in a rabbit's e yeball was measured in vivo. There was a 30-min time delay between obs ervations of aqueous glucose and blood glucose. The detection capabili ty and the reproducibility of the experiment are demonstrated and disc ussed. (C) 1998 Optical Society of America.