L. Irwig et al., A FLOW DIAGRAM TO FACILITATE SELECTION OF INTERVENTIONS AND RESEARCH FOR HEALTH-CARE, Bulletin of the World Health Organization, 76(1), 1998, pp. 17-24
Decisions about health care should be informed by systematic review of
valid research evidence on the effects of interventions on health out
comes that matter. If systematic review suggests it is likely that a h
ealth care intervention does more good than harm in some settings, que
stions must be addressed about the local applicability of the interven
tion, its cost-effectiveness, and feasibility of implementation. If sy
stematic review suggests that it is unlikely that an intervention does
more good than harm in any setting its use should be discouraged, whi
le existing interventions are improved or alternative interventions de
veloped. If it is uncertain whether an intervention does more good tha
n harm, further analysis of existing data or new controlled trials are
required. The article contains a flow diagram, which provides a struc
ture for making such decisions.