ENZYME STABILITY IN SYSTEMS WITH ORGANIC-SOLVENTS

This review deals with enzyme stability in organic solvent systems. Ba sed on the current state of the problem, catalytic activity is chosen as the main tool for testing enzyme stability. Various enzyme properti es being regarded as their ''stability'' at present, a classification of the types of enzyme stability most often discussed in the literatur e is put forward. Aggregation state of the biocatalytic system formed a basis for the analysis of enzyme stability in organic solvent system s. Regularities of enzyme function in homogeneous solutions in water-o rganic co-solvent mixtures and suspensions in practically anhydrous so lvents are discussed, kinetic data being analyzed in parallel to resul ts of structural studies. Based on the elaborated regularities, up-to- date methods for enzyme stabilization in organic solvent systems are c onsidered.