Background: The wide acceptance of laparoscopic cholecystectomy (LC) h
as resulted in increased rates of cholecystectomy. However, the increa
sed rate of LC bears the possibility of concomitantly missing other in
tra-abdominal pathologic states that exist concurrently with this proc
edure. The purpose of this report was to evaluate data on LC with rega
rd to missed pathologies of other organs in a clinical prospective fol
low-up. Methods: The clinical prospective follow-up of 676 patients tr
eated laparoscopically for gallstone disease at our unit since January
1993, was studied. Converted procedures were excluded from the follow
-up study. Results: Among 676 patients who underwent LC, 4 patients (0
.6%) required readmission for missed pathology of another organ. The d
iagnostic delay ranged from 2 weeks to 7 months. The readmissions were
due to colonic cancer (2 cases), carcinoma of the stomach (1 case), a
nd fibrosis of the mesenterium of small bowel causing ileus (1 case),
which are demonstrated in detail. According to retrospective analysis
of the symptoms, none of the patients had typical biliary pain at the
time of laparoscopic procedure. Conclusions: The demand for LC from pa
tients and practitioners is becoming increasingly more frequent, as al
l become aware of its benefits, However, on the basis of data from the
literature and this study, the authors would like to emphasize the ne
ed for careful history-taking, thorough investigation, and comparison
with gallstone symptoms before LC is performed. It is emphasized, howe
ver, that surgeons using laparoscopic approaches should learn techniqu
es of full diagnostic laparoscopy, which should be performed at the be
ginning of every procedure.